Marijuana Compound Halts Breast Cancer Tumor Growth

[Puffin13]

Marijuana Compound Halts Breast Cancer Tumor Growth
August 5, 2010 - Madrid, Spain

Madrid, Spain: The administration of THC reduces the tumor growth of metastatic breast cancer and "might constitute a new therapeutic tool for the treatment" of cancerous tumors, according to preclinical data published online in the journal Molecular Cancer.

Investigators from Complutense University in Madrid assessed the anti-tumor potential of THC and JWH-133, a non-psychotropic CB2 receptor-selective agonist, in the treatment of ErbB2-positive breast tumors – a highly aggressive form of breast cancer that is typically unresponsive to standard therapies.

Researchers reported, "both Delta-9-tetrahydrocannabinol ... and JWH-133 ...reduce tumor growth [and] tumor number [in mice]. ... [T]hese results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer."

In 2007, investigators at the California Pacific Medical Center Research Institute reported that the administration of the nonpsychoactive cannabinoid CBD limited breast cancer metastasis in a manner that was superior to comparable synthesized agents.

Previous preclinical studies assessing the anticancer properties of cannabinoids have shown that they inhibit the proliferation of a wide range of cancers, including brain cancer, prostate cancer, oral cancers, lung cancer, skin cancer, pancreatic cancer, biliary tract cancers, and lymphoma.

For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, "Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition," is available online at: http://www.molecular-cancer.com/content/9/1/196

[Stanky Danky]

Yet another study that provides evidence that marijuana kills cancer cells.

[Sir Niall of Essex-sire]

Full text article does not exist at link given.

[Boner]

Full text article does not exist at link given.

Not exactly rocket science to see he mistakenly added a full stop at the end of the link: http://www.molecular-cancer.com/content/9/1/196

(2 eye rolls for you).

[Kingdoc]

If aids turns on its heels well just about anything should .

[Puffin13]

Not exactly rocket science to see he mistakenly added a full stop at the end of the link: http://www.molecular-cancer.com/content/9/1/196 (2 eye rolls for you).

My apologies. I removed the full stop.

[sh@dy]

I am waiting for your reply Sir Niall

[Sir Niall of Essex-sire]

I am waiting for your reply Sir Niall

Firstly, i agree with one of the main points for discussion;

Remarkably, this is, to the best of our knowledge, the first report supporting that cannabinoids hamper not only tumor growth but also tumor generation.

In that more study is needed to 'back up' this study and further the research.

Second, this makes for interesting reading;

Potential antitumoral therapies based on the use of cannabinoids might be limited by their well known psychotropic actions such as dizziness, dry mouth, tiredness, muscle weakness, euphoria, myalgia and palpitations [6,35]. Although the benefit/risk ratio is potentially high for cannabinoid-based therapies, different strategies should be taken to avoid or at least minimize their side effects. Since most -if not all- of the psychoactive effects of cannabinoids are produced by the activation of central CB1 receptors [5,6], one reasonable approach would be targeting CB2 receptors selectively

It seems this is advising a form of treatment that makes use of some of the chemicals found in Cannabis, not Cannabis itself including the effects we all enjoy. This is interesting because advertising this as 'Cannabis reduces Cancer' would for me be misleading. Rather the study should be approached with the proviso that a chemical, or group of, found within Cannabis may be helpful when addressing this particular type of Breast Cancer. On the top of it, this seems like a good study IMO, i haven't read the methodology so that's obviously a limited statement on my behalf but i think the discussion is good.

However, i feel waving this study in the air as Cannabis stops Cancer is misleading, and also given the quote above, misrepresenting what the researchers are saying.

[Uncle Ron]

Excellent point(s) Sir Naill. If I may...

From the article:
"Conclusions
Taken together, these results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer."

Adding to SNoEs comments, we need to remember that this level of research and cancer management (yet to be clinically tested as stated) is so far beyond the psychotropic effects that most people seek and desire.

I also agree that stating in any capacity that cannabis stops or cures cancer is misleading, bordering on sheer ignorance of the facts. As I stated above but I will clarify, yet to be clinically tested means that tests have been conducted in laboratories and on mice, not with humans.

Here's the kicker,
"Remarkably, this is, to the best of our knowledge, the first report supporting that cannabinoids hamper not only tumor growth but also tumor generation."

This report was submitted in January 2010. Reread the quote again and then think about all the BS people have been floating around all these years. A cold slap in the face for some I would think.

I almost forgot, read any scientific article or paper on this subject and one will see that their working hypothesis uses words such as may, might, or could, and not what some hallucinate those words to mean - definitively will and can. BIG DIFFERENCE!

Time and research will tell.

[Sir Niall of Essex-sire]

Excellent point(s) Sir Naill. If I may...

From the article:
"Conclusions
Taken together, these results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer."

Adding to SNoEs comments, we need to remember that this level of research and cancer management (yet to be clinically tested as stated) is so far beyond the psychotropic effects that most people seek and desire.

I also agree that stating in any capacity that cannabis stops or cures cancer is misleading, bordering on sheer ignorance of the facts. As I stated above but I will clarify, yet to be clinically tested means that tests have been conducted in laboratories and on mice, not with humans.

Here's the kicker,
"Remarkably, this is, to the best of our knowledge, the first report supporting that cannabinoids hamper not only tumor growth but also tumor generation."

This report was submitted in January 2010. Reread the quote again and then think about all the BS people have been floating around all these years. A cold slap in the face for some I would think.

I almost forgot, read any scientific article or paper on this subject and one will see that their working hypothesis uses words such as may, might, or could, and not what some hallucinate those words to mean - definitively will and can. BIG DIFFERENCE!

Time and research will tell.

The last point you make, DUR, is extremely important.

For the MMJ activists to hold this is high regard is to rubbish all the previous 'evidence' for MMJ away?

Interesting thought....

[Stanky Danky]

Remarkably, this is, to the best of our knowledge, the first report supporting that cannabinoids hamper not only tumor growth but also tumor generation.

In that more study is needed to 'back up' this study and further the research.

The OP sites a previous 2007 study that found similar results. I know you'll do your best to deny any evidence that marijuana may be useful to fight cancer, but I thinks it's time to just start accepting it as possible. Here's a few links to articles that site other previous studies that found similar results. I know I've posted a couple of these before, but you seem to have forgotten they ever existed when posting that quote.


http://www.salem-news.com/articles/janu ... _11008.php

http://cancermarijuana.com/2009/04/04/a ... cer-cells/

http://health.usnews.com/health-news/fa ... ancer.html

http://www.sciencedaily.com/releases/20 ... 181217.htm

Another article that sites the previous 2007 study in the OP.
http://www.foxnews.com/story/0,2933,312132,00.html

http://www.nowpublic.com/thc_marijuana_ ... vard_study

http://jnci.oxfordjournals.org/cgi/cont ... t/djm268v1

http://scienceblogs.com/scientificactiv ... he_mun.php

http://www.newscientist.com/article/dn1 ... ancer.html

Looks like marijuana really is good medicine.

[Stanky Danky]

I almost forgot, read any scientific article or paper on this subject and one will see that their working hypothesis uses words such as may, might, or could, and not what some hallucinate those words to mean - definitively will and can. BIG DIFFERENCE!

Don't worry they use real science to figure out those cancer cells are on the retreat.

[bleak]

Isn't it amazing how it even says on the bottle "the flowering tops of cannabis sativa'. They already knew it back then.

People could buy this back in 1900 or whatever, but not anymore. WTF happened??

[Boner]

I think we need to embrace the fact that there are very positive signs that cannabis can help in the fight against cancer.

[Sir Niall of Essex-sire]

But SD, how do you reconcile the previous 'evidence' with the assertion that to these researchers theirs is the only research to have proven this link?

One's got to be right and the other wrong?